Joseph Lister The widespread introduction of antiseptic surgical methods was initiated by the publishing of the paper Antiseptic Principle of the Practice of Surgery in by Joseph Listerwhich was inspired by Louis Pasteur 's germ theory of putrefaction. Some of this work was anticipated by:
Gale Encyclopedia of Surgery: Antiseptics Definition An antiseptic is a substance that inhibits the growth and development of microorganisms. For practical purposes, antiseptics are routinely thought of as topical agents, for application to skin, mucous membranes, and inanimate objects, although a formal definition includes agents that are used internally, such as the urinary tract antiseptics.
Purpose Antiseptics are a diverse class of drugs that are applied to skin surfaces or mucous membranes for their anti-infective effects. This may be either bacteriocidal kills bacteria or bacteriostatic stops the growth of bacteria.
Their uses include cleansing of skin and wound surfaces after injury, preparation of skin surfaces prior to injections or surgical procedures, and routine disinfection of the oral cavity as part of a program of oral hygiene. Antiseptics are also used for disinfection of inanimate objects, including instruments and furniture surfaces.
Commonly used antiseptics for skin cleaning include benzalkonium chloride, chlorhexidine, hexachlorophine, iodine compounds, mercury compounds, alcohol, and hydrogen peroxide. Other agents that have been used for this purpose, but have largely been supplanted by more effective or safer agents, include boric acid and volatile oils such as methyl salicylate oil of wintergreen.
Chlorhexidine shows a high margin of safety when applied to mucous membranes, and has been used in oral rinses and preoperative total body washes. Benzalkonium chloride and hexachlorophine are used primarily as hand scrubs or face washes.
Benzalkonium may also find application as a disinfecting agent for instruments, and in low concentration as a preservative for drugs including ophthalmic solutions. Benzalkonium chloride is inactivated by organic compounds, including soap, and must not be applied to areas that have not been fully rinsed.
Iodine compounds include tincture of iodine and povidone iodine compounds.
Iodine compounds have the broadest spectrum of all topical anti-infectives, with action against bacteria, fungi, viruses, spores, protozoa, and yeasts. Iodine tincture is highly effective, but its alcoholic component is drying and extremely irritating when applied to abraded scraped or rubbed skin.
Povidone iodine, an organic compound, is less irritating and less toxic, but not as effective. Povidone iodine has been used for hand scrubs and disinfection of surgical sites.
Aqueous solutions of iodine have also been used as antiseptic agents, but are less effective than alcoholic solutions and less convenient to use that the povidone iodine compounds.
Hydrogen peroxide acts through the liberation of oxygen gas. Although the antibacterial activity of hydrogen peroxide is relatively weak, the liberation of oxygen bubbles produces an effervescent action, which may be useful for wound cleansing through removal of tissue debris.
The activity of hydrogen peroxide may be reduced by the presence of blood and pus. Thimerosol Mersol is a mercury compound with activity against bacteria and yeasts.
Prolonged use may result in mercury toxicity. Recommended dosage Dosage varies with product and intended use. Patients should ask a physician. Precautions Precautions vary with individual product and use.
Hypersensitivity reactions should be considered with organic compounds such as chlorhexidine, benzalkonium and hexachlorophine. Skin dryness and irritation should be considered with all products, but particularly with those containing alcohol.
Systemic toxicity may result from ingestion of iodine-containing compounds or mercury compounds.The mechanism of antimicrobial action of antiseptics and disinfectants has been researched by A. D. Russel from the Welsh school of pharmacy, the conclusion drawn is the target sites and concentrations of the antiseptic/disinfectant were the dependent factors.
May 02, · Create your citations, reference lists and bibliographies automatically using the APA, MLA, Chicago, or Harvard referencing styles. It's fast and free! Chemical germicides including disinfectants and antiseptics are used in a variety of applications from sterilizing medical instruments at hospitals to cleaning a household kitchen counter.
Learn antiseptics microbiology with free interactive flashcards. Choose from different sets of antiseptics microbiology flashcards on Quizlet. Learn lab exam 3 disinfectants and antiseptics with free interactive flashcards.
Choose from different sets of lab exam 3 disinfectants and antiseptics flashcards on Quizlet.
Do antiseptics and disinfectants really work? Let’s find out in this biology lab where you’ll learn how to grow microbes on a dipslide and test the effectiveness of .